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抗原
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GABA Transporter (GAT) 2
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目标物种
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Rat (Rattus)
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抗体来源
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Rabbit
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克隆
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多克隆抗体
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状态
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Affinitiy-purified
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描述
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Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-2 is found in a wide range of neuronal and non-neuronal cells including dendrites and axon terminals as well as epithelial cells and cells forming the pia and arachnoid complex (Conti et al., 1999).
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特异性
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Specific for the ~82k GAT-2 protein.
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