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anti-8 Hydroxyguanosine (8-OHDG) antibody

概述

图像 anti-8 Hydroxyguanosine (8-OHDG) antibody
抗原: 8 Hydroxyguanosine (8-OHDG)
克隆: 单克隆抗体 (N45-1)
应用范围: Immunohistochemistry (IHC), ELISA
抗体来源: Mouse
16 references available 16 references available
规格: 100 ug (相似抗体)
价格: 9.034,60 ¥   (加上运费和增值税, Invoice in EUR)
货号: ABIN335419
发货时间: Ships within 5 to 7 Business days
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详细信息  » anti-8 Hydroxyguanosine (8-OHDG) antibody

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抗原 8 Hydroxyguanosine (8-OHDG)
免疫原 8-OHdG-conjugated Keyhole Limpet Hemocyanin
抗体来源 Mouse
克隆 单克隆抗体
状态 Lyophilized
抗体同种型 IgG1-kappa »相配的二抗
描述 8-hydroxy-2'-deoxyguanosine (8-OHdG) is a product of oxidatively damaged DNA formed by hydroxy radical, singlet oxygen and direct photodynamic action. Anti 8-OHdG monoclonal antibody (clone N45.1) is highly specific for 8-OHdG, and is suitable for immunohistochemistry. Cross reactivity have been checked for 8-OHdG analogues (guanosine(G),7-methyl-G, 6-SH-G, 8-Bromo-G, dA, dC, dT, dI, dU, dG, O6-methyl-dG, 8-OHdA, guanine(Gua),O6-methyl-Gua, 8-OH-Gua, uric acid, urea, creatine, creatinine, 8-sulfhydryl-G, 8-OH-G).
克隆 N45-1
特异性 8-OHDG in all species. No observable crossreactivity for the following analogues: guanosine (G), 7methylG, 6SHG, 8bromoG, dA, dC, dT, dI, dU, dG, O6methyldG, 8OHdA, guanine (Gua), O6methylGua, 8OHGua, uric acid, Urea, creatine, creatinine Slight but minimal (<1%) crossreactivity for the following analogues: 8sulfhydrylG and 8OHG 1

使用细节  » anti-8 Hydroxyguanosine (8-OHDG) antibody

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应用范围 Immunohistochemistry (IHC), ELISA
应用备注 Tested for IHC and ELISA. User should determine optimum titer for each application.
纯化 Prepared as ascites then ammonium sulphate purified
缓冲液 Lyophilized as 100 ug/mL IgG in10mM Phosphate buffered saline, pH7.4 containing 1.0% BSA.
贮藏 Less than 20oC.
研究领域 DNA/RNA
限制 For Research Use only

参考文献  » anti-8 Hydroxyguanosine (8-OHDG) antibody

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参考文献 Hattori, Nishigori, Tanaka et al.: "8-hydroxy-2'-deoxyguanosine is increased in epidermal cells of hairless mice after chronic ultraviolet B exposure." In: The Journal of investigative dermatology, Vol. 107, Issue 5, pp. 733-7, 1996 (PubMed)

Toyokuni, Tanaka, Hattori et al.: "Quantitative immunohistochemical determination of 8-hydroxy-2'-deoxyguanosine by a monoclonal antibody N45.1: its application to ferric nitrilotriacetate-induced renal carcinogenesis model." In: Laboratory investigation; a journal of technical methods and pathology, Vol. 76, Issue 3, pp. 365-74, 1997 (PubMed)

Tanaka, Nishiyama, Okada et al.: "Induction and nuclear translocation of thioredoxin by oxidative damage in the mouse kidney: independence of tubular necrosis and sulfhydryl depletion." In: Laboratory investigation; a journal of technical methods and pathology, Vol. 77, Issue 2, pp. 145-55, 1997 (PubMed)

Ihara, Toyokuni, Uchida et al.: "Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes." In: Diabetes, Vol. 48, Issue 4, pp. 927-32, 1999 (PubMed)

Ichiseki, Kaneuji, Katsuda et al.: "DNA oxidation injury in bone early after steroid administration is involved in the pathogenesis of steroid-induced osteonecrosis." In: Rheumatology (Oxford, England), Vol. 44, Issue 4, pp. 456-60, 2005 (PubMed)

Lee, Cho, Yokozawa: "Protective effect of persimmon (Diospyros kaki) peel proanthocyanidin against oxidative damage under H2O2-induced cellular senescence." In: Biological & pharmaceutical bulletin, Vol. 31, Issue 6, pp. 1265-9, 2008 (PubMed)

Sato, Harada, Ikeda et al.: "Hepatic stellate cells are activated around central scars of focal nodular hyperplasia of the liver--a potential mechanism of central scar formation." In: Human pathology, Vol. 40, Issue 2, pp. 181-8, 2009 (PubMed)

Ribaldo, Souza, Biswas et al.: "Green tea (Camellia sinensis) attenuates nephropathy by downregulating Nox4 NADPH oxidase in diabetic spontaneously hypertensive rats." In: The Journal of nutrition, Vol. 139, Issue 1, pp. 96-100, 2008 (PubMed)

Du, Wooten, Gearing et al.: "Age-associated oxidative damage to the p62 promoter: implications for Alzheimer disease." In: Free radical biology & medicine, Vol. 46, Issue 4, pp. 492-501, 2009 (PubMed)

Iqbal, Okazaki, Okada: "Curcumin attenuates oxidative damage in animals treated with a renal carcinogen, ferric nitrilotriacetate (Fe-NTA): implications for cancer prevention." In: Molecular and cellular biochemistry, Vol. 324, Issue 1-2, pp. 157-64, 2009 (PubMed)

Sakano, Takahashi, Wang et al.: "Plasma 3-nitrotyrosine, urinary 8-isoprostane and 8-OHdG among healthy Japanese people." In: Free radical research, Vol. 43, Issue 2, pp. 183-92, 2009 (PubMed)

Song, Li, Ootsuyama et al.: "Urea, the most abundant component in urine, cross-reacts with a commercial 8-OH-dG ELISA kit and contributes to overestimation of urinary 8-OH-dG." In: Free radical biology & medicine, Vol. 47, Issue 1, pp. 41-6, 2009 (PubMed)

Silva, Rosales, Biswas et al.: "Diabetic retinal neurodegeneration is associated with mitochondrial oxidative stress and is improved by an angiotensin receptor blocker in a model combining hypertension and diabetes." In: Diabetes, Vol. 58, Issue 6, pp. 1382-90, 2009 (PubMed)

Min, Park, Kim et al.: "Effect of oxidative stress on birth sizes: consideration of window from mid pregnancy to delivery." In: Placenta, Vol. 30, Issue 5, pp. 418-23, 2009 (PubMed)

Yamazaki, Miwa, Toyokuni et al.: "Effect of edaravone, a novel free radical scavenger, supplemented to cardioplegia on myocardial function after cardioplegic arrest: in vitro study of isolated rat heart." In: Heart and vessels, Vol. 24, Issue 3, pp. 228-35, 2009 (PubMed)

Herbas, Thekisoe, Inoue et al.: "The effect of alpha-tocopherol transfer protein gene disruption on Trypanosoma congolense infection in mice." In: Free radical biology & medicine, Vol. 47, Issue 10, pp. 1408-13, 2009 (PubMed)