详细信息 » anti-Oazin (Antizyme inhibitor 1) antibody

抗原	Oazin (Antizyme inhibitor 1)
免疫原	Affinity-purified Antizyme inhibitor from rat liver
目标物种	Human, Mouse (Murine), Rat (Rattus)
克隆	单克隆抗体
状态	Ion exchange chromatography
抗体同种型	IgG3 »相配的二抗
描述	ODC (ornithine decarboxylase) is a key enzyme in polyamine biosynthesis pathway. The degradation of ODC catalyzed by the 26S proteasome is accelerated by antizyme, an ODC inhibitory protein induced poliamine. Antizyme inhibitor 1 (AZI) specifically binds to antizyme with a higher affinity than that of ODC and thus can release active ODC from inactive ODC-antizyme complex. AZI consists of about 450 amino acids and 50 kDa protein. AZI is highly homologous to ODC but retains no enzymatic activity. AZI is a short-living protein that undergoes proteasomal degradation and the degradation is inhibited by interaction with antizyme. AZI is induced in cells and tissues following growth stimulation, is elevated in some tumors. AZI overexpression leads to increased rates of cell proliferation in the rat carcinoma cells and mouse fibroblasts and this effect appears to be partially independent of the ability of AZI to interact with antizyme. It has been also reported that antizyme and AZI localize to centrosome and may play an important role in the regulation of centrosome homeostasis and oncogenesis.
克隆	HI-12
抗体来源	Mouse

使用细节 » anti-Oazin (Antizyme inhibitor 1) antibody

应用范围	Western Blotting (WB), Immunocytochemistry (ICC)
应用备注	WB: 0.25 ug/mL. ICC 30 ug/mL
浓度	0.25 mg/ml
纯化	Ion exchange chromatography
缓冲液	PBS [containing 2 % Block Ace as a stabilizer, 0.1 %Proclin as a bacteriostat]
贮藏	Store below
研究领域	Enzymes, Metabolism, Proteasome
限制	For Research Use only

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	抗原:	Oazin (Antizyme inhibitor 1)
	克隆:	单克隆抗体 (HI-12)
	应用范围:	Western Blotting (WB), Immunocytochemistry (ICC)
	目标物种:	Human, Mouse (Murine), Rat (Rattus)
	抗体来源:	Mouse
	规格:	50 ug (0.25 mg/ml)
	价格:	884,12 $ (加上运费$25和增值税, Invoice in EUR)
	货号:	ABIN303592
	发货时间:	Ships within 5 Business days