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anti-nuclease-sensitive element-binding protein 1 (YBX1) (N-Term) antibody
概述
| 抗原: | Nuclease-sensitive element-binding protein 1 (YBX1) |
| 克隆: | 多克隆抗体 |
| 应用范围: | Western Blotting (WB), Immunohistochemistry (IHC) |
| 目标物种: | Human |
| 抗体来源: | Rabbit |
|
3 references available |
| 规格: | |
| 价格: | 2.058,67 ¥ (加上运费和增值税, Invoice in EUR) |
| 货号: | ABIN155053 |
| 发货时间: | Ships within 1 Business day |
详细信息 » anti-nuclease-sensitive element-binding protein 1 (YBX1) (N-Term) antibody
| 抗原 | Nuclease-sensitive element-binding protein 1 (YBX1) |
| 基因ID | 4904 |
| 目标物种 | Human |
| 克隆 | 多克隆抗体 |
| 状态 | Affinitiy-purified |
| 抗体同种型 | IgG »相配的二抗 |
| 描述 | Members of Y-box binding protein family all contain a DNA binding domain, called the cold shock domain, comprising of 80 amino acids, which is highly conserved from prokaryotes to eukaryotes. Y-box binding protein-1 (YB-1) is a prototypic member of this family and was originally isolated as a DNA binding protein recognizing the Y-box sequence within the MHC class II gene promoter region. This box is found in the promoter region of several genes involved in positive regulation of cell cycle, such as proliferating cell nuclear antigen, DNA topoisomerase IIa, DNA-polymerase-alpha and cyclins. Consequently, YB-1 is thought to play crucial roles for cell proliferation and carcinogenesis. YB-1 has been reported to be a prognostic marker of breast cancer, ovarian cancer, lung cancer, thyroid cancer, and synovial sarcoma. These findings indicate the significance of YB-1 for the progression of malignant diseases. Alternative names: BP-8, CSDA2, CSDB, DBPB, MDR-NF1, MGC104858, MGC110976, MGC117250, NSEP-1, NSEP1, YB-1, YB1, YBX1, DNA-binding protein B, Y box-binding protein I, nuclease sensitive element binding protein 1. |
| 抗体来源 | Rabbit |
使用细节 » anti-nuclease-sensitive element-binding protein 1 (YBX1) (N-Term) antibody
| 应用范围 | Western Blotting (WB), Immunohistochemistry (IHC) |
| 应用备注 | WB: 1:1000. IHC (p): 1:50 to 1:200 depending on type of tissue |
| 浓度 | 200ug/ml |
| 贮藏 | Store aliquots at -20 C. Avoid repeated thawing and freezing |
| 研究领域 | Cancer |
| 限制 | For Research Use only |
参考文献 » anti-nuclease-sensitive element-binding protein 1 (YBX1) (N-Term) antibody
| 参考文献 |
Krohn R, Raffetseder U, Bot I et al.: "Y-Box Binding Protein-1 Controls CC Chemokine Ligand-5 (CCL5) Expression in Smooth Muscle Cells and Contributes to Neointima Formation in Atherosclerosis-Prone Mice" In: Circulation
, Vol. Epub ahead of print, 2007 (PubMed)
Frye, Halfter, Djudjaj et al.: "Y-box protein-1 is actively secreted through a non-classical pathway and acts as an extracellular mitogen." In: EMBO reports , Vol. 10, Issue 7, pp. 783-9, 2009 (PubMed) Rauen, Raffetseder, Frye et al.: "YB-1 acts as ligand for Notch-3 receptors and modulates receptor activation." In: The Journal of biological chemistry , 2009 (PubMed) |
图像 » anti-nuclease-sensitive element-binding protein 1 (YBX1) (N-Term) antibody
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