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anti-CEACAM5 (CEA, CD66e) antibody

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图像 anti-CEACAM5 (CEA, CD66e) antibody
抗原: CEACAM5 (CEA, CD66e)
克隆: 单克隆抗体 (26-3-13)
应用范围: Flow Cytometry (FACS), Cell-ELISA (cELISA), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
目标物种: Human
抗体来源: Mouse
9 references available 9 references available
规格: 100 ug (1mg/ml)
价格: 2.058,67 ¥   (加上运费和增值税, Invoice in EUR)
货号: ABIN108727
发货时间: Ships within 1 to 2 Business days
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详细信息  » anti-CEACAM5 (CEA, CD66e) antibody

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抗原 CEACAM5 (CEA, CD66e)
免疫原 Immunisation with extracted protein of CEACAM5
目标物种 Human
克隆 单克隆抗体
状态 Purified
抗体同种型 IgG1 »相配的二抗
描述 CEACAM5 (CEA-related cell adhesion molecule 5, CEA) belongs to the carcinoembryonic antigen (CEA) gene family (5). It encodes a glycosyl phosphatidylinositol (GPI)- linked glycoprotein with a Mr of 180,000-200,000 which is most strongly expressed on epithelial cells of the fetal and adult colon and to a minor extent on epithelial cells of the stomach and sweat glands, squamous epithelial cell of the tongue, esophagus and cervix. CEACAM5 is used as a tumor marker for early detection of recurrent disease due its expression in adenocarcinomas of the colon, lung, breast, stomach and pancreas and in mucinous ovarian carcinomas (5). Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by six immunoglobulin constant-like A (A1, A2, A3) and B domains (B1, B2, B3).
克隆 26-3-13
抗体来源 Mouse
特异性 Anti-human CEACAM5 (CEA, CD66e)

使用细节  » anti-CEACAM5 (CEA, CD66e) antibody

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应用范围 Flow Cytometry (FACS), Cell-ELISA (cELISA), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
应用备注 Flow cytometry: 1.2 ug/10^6 cells. ELISA: 1:200 - 1:400 CELISA: 1:200. Western blot: 4ug/ml. Immunohistology: 1-2 ug/10^6 cells (on cryosections)
浓度 1mg/ml
纯化 Protein G
缓冲液 Phosphate buffered saline, pH 7.2
贮藏 Short term: 2°C - 8°C. Long term: -20°C (avoid repeated freezing and thawing)
研究领域 Receptors, Cancer, Receptors, Cell/Tissue Markers, Cancer
限制 For Research Use only

参考文献  » anti-CEACAM5 (CEA, CD66e) antibody

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参考文献 Strobel, Strobel, Bross et al.: "Effects of human bone marrow stroma on the growth of human tumor cells." In: Cancer research , Vol. 49, Issue 4, pp. 1001-7, 1989 (PubMed)

Grunert, AbuHarfeil, Schwarz et al.: "Two CEA and three NCA species, although distinguishable by monoclonal antibodies, have nearly identical peptide patterns." In: International journal of cancer. Journal international du cancer , Vol. 36, Issue 3, pp. 357-62, 1985 (PubMed)

Thompson, Moessinger, Reichardt et al.: "A polymerase-chain-reaction assay for the specific identification of transcripts encoded by individual carcinoembryonic antigen (CEA)-gene-family members." In: International journal of cancer. Journal international du cancer , Vol. 55, Issue 2, pp. 311-9, 1993 (PubMed)

Krop-Watorek, Laskowska, Salwa et al.: "CEA-related proteins on human urothelial cell lines of different transformation grades." In: Cancer letters , Vol. 139, Issue 1, pp. 15-22, 1999 (PubMed)

Schoelzel, Zimmermann, Schwarzkopf et al.: "Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas." In: The American journal of pathology , Vol. 156, Issue 2, pp. 595-605, 2000 (PubMed)

Baczy?ska, Wietrzyk, Madej et al.: "The tumorigenic potential of human CX-1 colon adenocarcinoma cells depends on carcinoembryonic antigen (CEACAM5) expression." In: Cellular & molecular biology letters , Vol. 8, Issue 2, pp. 471-86, 2003 (PubMed)

Schmitter, Agerer, Peterson et al.: "Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens." In: The Journal of experimental medicine , Vol. 199, Issue 1, pp. 35-46, 2004 (PubMed)

Kammerer, Riesenberg, Weiler et al.: "The tumour suppressor gene CEACAM1 is completely but reversibly downregulated in renal cell carcinoma." In: The Journal of pathology , Vol. 204, Issue 3, pp. 258-67, 2004 (PubMed)

Noeckel, van den Engel, Winter et al.: "Characterization of gastric adenocarcinoma cell lines established from CEA424/SV40 T antigen-transgenic mice with or without a human CEA transgene." In: BMC cancer , Vol. 6, pp. 57, 2006 (PubMed)